Adenosine A2A-R Polyclonal Antibody

ADORA2A encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. Adenosine A2a receptor, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

The Adenosine A2A-R Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Adenosine A2A receptors in various biological samples. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The Adenosine A2A-R Polyclonal Antibody exhibits exceptional affinity and selectivity towards Adenosine A2A receptors, making it an ideal choice for researchers and scientists working in the field of molecular biology and pharmacology. It has been extensively validated for its specificity and sensitivity, ensuring accurate and reproducible results.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It can be used in both in vitro and in vivo studies, allowing for comprehensive investigations into the expression and localization of Adenosine A2A receptors in various tissues and cell types.

The Adenosine A2A-R Polyclonal Antibody is provided in a convenient and ready-to-use format, allowing for easy integration into existing experimental protocols. It is supplied in a liquid form, ensuring ease of handling and minimizing the risk of contamination.

With its exceptional performance and reliability, the Adenosine A2A-R Polyclonal Antibody is an indispensable tool for researchers and scientists seeking to unravel the intricate mechanisms underlying Adenosine A2A receptor signaling pathways.