AF-4 Polyclonal Antibody

AFF1 encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, AFF1has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.

The AF-4 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of AF-4 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards AF-4 protein.

The AF-4 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to accurately assess AF-4 protein levels and localization in different tissues and cell types.

With its superior sensitivity, this antibody allows for the detection of even low levels of AF-4 protein, making it an ideal choice for both qualitative and quantitative analysis. Its robust performance ensures reliable and reproducible results, facilitating precise experimental interpretations.

Furthermore, the AF-4 Polyclonal Antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reliability. It is supplied in a convenient format, ready for immediate use in various experimental settings.

In summary, the AF-4 Polyclonal Antibody is a valuable tool for researchers studying AF-4 protein expression and its role in various biological processes. Its high specificity, sensitivity, and reliability make it an indispensable asset in the field of molecular biology and biomedical research.