Akt1/3 Polyclonal Antibody

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

The Akt1/3 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Akt1 and Akt3 proteins in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Akt1/3 Polyclonal Antibody is designed to recognize both Akt1 and Akt3 proteins, which are members of the Akt family of serine/threonine kinases. These proteins play a critical role in regulating cell growth, survival, and metabolism, and are frequently dysregulated in cancer and other diseases.

This antibody has been extensively tested and validated for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to be highly specific and sensitive, with minimal cross-reactivity with other proteins.

The Akt1/3 Polyclonal Antibody is supplied in a convenient format, with a concentration of 1 mg/mL. It is suitable for use in a variety of research applications, including cancer research, cell signaling, and drug discovery.

Overall, the Akt1/3 Polyclonal Antibody is a highly reliable and effective tool for the detection of Akt1 and Akt3 proteins in biological samples. Its high specificity and sensitivity make it an ideal choice for researchers looking to study the role of these proteins in various biological processes.