Akt1 Polyclonal Antibody

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

The Akt1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Akt1 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity towards Akt1. With its exceptional performance, this antibody enables accurate and precise identification of Akt1 in Western blotting, immunohistochemistry, and immunofluorescence applications.

The Akt1 Polyclonal Antibody exhibits excellent specificity, exhibiting minimal cross-reactivity with other Akt isoforms. This feature allows for the specific detection of Akt1, facilitating the study of its role in various cellular processes, including cell survival, proliferation, and metabolism. Moreover, this antibody has been extensively validated in multiple experimental settings, guaranteeing consistent and reproducible results.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage. The Akt1 Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins. Its versatility makes it an ideal choice for researchers and scientists working in diverse fields, such as cancer biology, signal transduction, and drug discovery.

In summary, the Akt1 Polyclonal Antibody is a superior research tool that offers exceptional sensitivity, specificity, and versatility. Its reliable performance and ease of use make it an indispensable asset for any laboratory seeking to investigate the role of Akt1 in cellular processes.