ALK Polyclonal Antibody

ALK encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. ALK tyrosine kinase receptor comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

The ALK Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of anaplastic lymphoma kinase (ALK) protein expression. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional quality and reliability in experimental applications.

The ALK Polyclonal Antibody exhibits a high affinity for the ALK protein, enabling accurate and precise detection in various sample types, including tissue sections, cell lysates, and immunoprecipitates. Its exceptional specificity ensures minimal cross-reactivity with other proteins, enhancing the reliability of experimental results.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its versatility allows for the investigation of ALK protein expression and localization in diverse research areas, such as cancer biology, developmental biology, and signal transduction pathways.

The ALK Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming reconstitution or dilution steps. The antibody is also available in various sizes to accommodate different experimental requirements.

With its exceptional sensitivity, specificity, and ease of use, the ALK Polyclonal Antibody is an indispensable tool for researchers seeking to unravel the complexities of ALK protein expression and its role in various biological processes. Trust in its superior performance to advance your research and contribute to scientific discoveries in the field.