Amphiphysin II Polyclonal Antibody

BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin.

Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

The Amphiphysin II Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Amphiphysin II protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional sensitivity and specificity.

Amphiphysin II is a crucial protein involved in various cellular processes, including endocytosis, synaptic vesicle recycling, and cytoskeletal organization. Its dysregulation has been implicated in several pathological conditions, such as neurodegenerative disorders and cancer. Therefore, the accurate detection and quantification of Amphiphysin II protein are of utmost importance in both basic research and clinical applications.

The Amphiphysin II Polyclonal Antibody exhibits outstanding performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications. It recognizes the target protein with high affinity and specificity, enabling precise localization and quantification of Amphiphysin II in various tissue types and cell lines.

This antibody has been rigorously validated using a wide range of experimental approaches, ensuring its reliability and reproducibility. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and specific results. Additionally, it demonstrates excellent stability and consistency, allowing for long-term storage and repeated use without compromising its performance.

The Amphiphysin II Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient format, allowing for easy integration into existing laboratory protocols and workflows.

In summary, the Amphiphysin II Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of Amphiphysin II protein. Its exceptional performance in various applications, combined with its reliability and ease of use, make it an invaluable asset for researchers and clinicians alike.