AMPK Beta1 Polyclonal Antibody

Protein kinase AMP-activated non-catalytic subunit beta 1 encoded by PRKAB1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

The AMPK Beta1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of AMP-activated protein kinase (AMPK) Beta1 subunit. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reproducibility.

The AMPK Beta1 Polyclonal Antibody exhibits exceptional sensitivity and specificity, making it an ideal choice for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes the Beta1 subunit of AMPK across a wide range of species, enabling researchers to study the role of AMPK in diverse biological systems.

With its superior performance, this antibody allows for accurate and precise quantification of AMPK Beta1 expression levels in different tissues and cell types. Its high affinity and low background ensure reliable and reproducible results, facilitating the elucidation of AMPK Beta1's involvement in cellular processes such as energy homeostasis, metabolism, and autophagy.

The AMPK Beta1 Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It is provided in a liquid form, allowing for easy handling and minimizing the risk of sample contamination.

In summary, the AMPK Beta1 Polyclonal Antibody is a top-quality research tool that offers exceptional sensitivity, specificity, and reproducibility. Its versatility and reliability make it an indispensable asset for scientists studying the intricate mechanisms of AMPK Beta1 and its implications in various physiological and pathological conditions.