anti- AATF antibody

Delve into the intricacies of cell cycle regulation and DNA repair with our Anti-AATF Antibody, available in a 100µg size. AATF, also known as apoptosis-antagonizing transcription factor, plays a pivotal role in DNA damage response and anti-apoptotic pathways. Understanding the function of AATF is essential for unraveling the complexities of cellular stress responses and their impact on cancer and other diseases.

Our meticulously designed antibody is tailored to specifically target AATF with exceptional specificity and sensitivity, enabling precise detection and quantification in various research applications. Whether you are investigating DNA repair mechanisms, studying apoptosis regulation, or exploring the role of AATF in cellular stress adaptation, this antibody empowers you to make meaningful discoveries.

The 100µg size ensures you have ample supply for multiple experiments, reducing the need for frequent reorders and ensuring uninterrupted progress in your research. Each batch of our Anti-AATF Antibody undergoes stringent quality control measures to guarantee consistent performance and reliability in your experiments. Join leading researchers in the field of DNA damage response and apoptosis with this versatile and trusted antibody.

Product Name

AATF antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

IMMUNOGEN INFORMATION

Immunogen

apoptosis antagonizing transcription factor

Synonyms

AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube

Observed MW

63 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:200-1:2000; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q9NY61

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