SKU(재고 관리 코드):FNab00026
anti- ABAT antibody
anti- ABAT antibody
Explore the intricate world of neurotransmitter metabolism with our Anti-ABAT Antibody, available in a 100µg size. ABAT, also known as 4-aminobutyrate aminotransferase or GABA transaminase, is a key enzyme in the catabolism of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the central nervous system. Understanding the role of ABAT is essential for unraveling the complexities of neurotransmission and its impact on neurological and psychiatric disorders.
Our meticulously designed antibody is tailored to specifically target ABAT with exceptional specificity and sensitivity, enabling precise detection and quantification in various research applications. Whether you are studying GABA metabolism, exploring the role of ABAT in neurotransmitter regulation, or investigating its potential as a therapeutic target in neurological disorders, this antibody is an invaluable tool for your research endeavors.
The 100µg size ensures you have ample supply for multiple experiments, reducing the need for frequent reorders and ensuring uninterrupted progress in your research. Each batch of our Anti-ABAT Antibody undergoes rigorous quality control measures to guarantee consistent performance and reliability in your experiments. Elevate your neurotransmitter metabolism research with this versatile and trusted antibody.
Product Name
ABAT antibody
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
BACKGROUND
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
IMMUNOGEN INFORMATION
Immunogen
4-aminobutyrate aminotransferase
Synonyms
ABAT, FLJ17813, GABA aminotransferase, GABA AT, GABA T, GABA transaminase, GABAT, L AIBAT
Observed MW
49 kDa
APPLICATION
Tested Application
ELISA, WB, IHC, IF
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
UNIPROT INFORMATION
UniProt ID
IMAGES
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab00026(ABAT antibody) at dilution of 1:100
Immunofluorescence analysis of A549 cells using FNab00026(ABAT antibody). Blue: DAPI for nuclear staining.
human liver tissue were subjected to SDS PAGE followed by western blot with FNab00026(ABAT antibody) at dilution of 1:1000