anti- ABL2 antibody

Elevate your cellular signaling research with our Anti-ABL2 Antibody. With a substantial 100µg supply, this antibody equips you with the precision and reliability needed to pioneer new frontiers in understanding ABL2 and its role in cellular processes.

ABL2, a non-receptor tyrosine kinase, is a key player in cellular signal transduction and has been implicated in various diseases. Our antibody is meticulously designed to specifically target ABL2 with exceptional sensitivity. Through rigorous validation, it ensures consistent and dependable results, providing you with the confidence to explore cellular signaling pathways.

Produced using state-of-the-art techniques, this antibody is a valuable tool for a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence assays. Its 100µg size ensures you have ample resources for your experiments.

Whether you're investigating kinase activity, cellular proliferation, or disease mechanisms, our Anti-ABL2 Antibody is your trusted research companion. Its high-quality formulation makes it an indispensable asset for your laboratory, enabling you to make groundbreaking discoveries and contribute to the advancement of cellular biology.

Empower your research with the precision and reliability of our Anti-ABL2 Antibody. Order your 100µg supply today and embark on a journey of discovery with confidence.

Product Name

ABL2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10(involved in movement); CTTN(involved in signaling); or TUBA1 and TUBB(microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

IMMUNOGEN INFORMATION

Immunogen

v-abl Abelson murine leukemia viral oncogene homolog 2(arg, Abelson-related gene)

Synonyms

Abelson related gene protein, ABL2, ABLL, ARG, FLJ22224, FLJ31718, FLJ41441, Tyrosine protein kinase ABL2, Tyrosine protein kinase ARG

Observed MW

127 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC, IP

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100; IP: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

P42684

IMAGES

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab00053(ABL2 Antibody) at dilution of 1:50

IP Result of anti-ABL2 (IP:FNab00053, 4ug; Detection:FNab00053 1:500) with HeLa cells lysate 1200ug.

HeLa cells were subjected to SDS PAGE followed by western blot with FNab00053(ABL2 antibody) at dilution of 1:500