anti- ACD antibody

Shine a light on telomere maintenance with our Anti-ACD Antibody. With a substantial 100µg supply, this antibody empowers you to delve into ACD (also known as TPP1) and its pivotal role in protecting and regulating telomeres, the DNA sequences at the ends of chromosomes.

ACD is a key component of the shelterin complex, which safeguards telomere integrity and regulates telomerase activity. Dysfunction of telomeres and shelterin proteins is associated with aging and various diseases. Our antibody is expertly crafted to specifically target ACD, ensuring precise and sensitive detection.

Utilizing state-of-the-art techniques, this antibody is designed to provide reliable and consistent results. Whether you're conducting chromatin immunoprecipitation (ChIP), co-immunoprecipitation, or other assays to study telomere biology and its implications in aging and cancer, this antibody is your reliable research partner.

Investigations into telomere maintenance are vital for understanding cellular aging and cancer development. Our Anti-ACD Antibody can contribute to advancements in these fields by enabling accurate detection of ACD and its interactions with telomeric DNA.

Elevate your research with the precision and reliability of our Anti-ACD Antibody. Secure your 100µg supply today and embark on a journey to uncover the mysteries of telomere biology.

Product Name

ACD antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the shelterin complex(telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

IMMUNOGEN INFORMATION

Immunogen

adrenocortical dysplasia homolog(Mouse)

Synonyms

ACD, PIP1, PTOP, TINT1, TPP1

Observed MW

58 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:5000

UNIPROT INFORMATION

UniProt ID

Q96AP0

IMAGES

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00078(ACD Antibody) at dilution of 1:1500