anti- Aconitase 2 antibody

Illuminate the roles of Aconitase 2 in the citric acid cycle with our Anti-Aconitase 2 Antibody. This essential tool, available in a generous 100µg size, provides you with the precision and reliability needed to explore Aconitase 2 and its involvement in cellular energy metabolism.

Aconitase 2, a critical enzyme in the citric acid cycle, plays a pivotal role in converting citrate to isocitrate, a fundamental step in energy production. Our antibody is meticulously crafted to specifically target Aconitase 2 with remarkable sensitivity. Thoroughly validated, it ensures consistent and dependable results, empowering you to delve into the intricacies of cellular energy production.

Produced using state-of-the-art techniques, this antibody is sourced from rabbit hosts, featuring a polyclonal clonality that broadens its range of binding capabilities. Its versatility makes it an ideal choice for diverse applications, including Western blotting, immunohistochemistry, and immunofluorescence assays.

Whether you're unraveling the citric acid cycle mechanisms, studying mitochondrial metabolism, or exploring diseases related to Aconitase 2 dysregulation, our Anti-Aconitase 2 Antibody is your trusted research companion. Its high-quality formulation and generous 100µg size ensure it is an indispensable asset for your laboratory, enabling groundbreaking discoveries and contributions to cellular metabolism research.

Elevate your research with the precision and reliability of our Anti-Aconitase 2 Antibody. Secure your 100µg supply today and embark on a journey to uncover the intricacies of energy metabolism.

Product Name

Aconitase 2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

ACO2(aconitate hydratase, mitochondrial) is also named as citrate hydro-lyase and belongs to the aconitase/IPM isomerase family. It plays a key function in cellular energy production, and loss of its activity has a major impact on cellular and organismal survival. Western blot shows two bands of 83 kDa and 40 kDa. The 40 kDa fragment decreases with age and oxidative stress, whereas other fragmentation products with molecular weights between 40 and 83 kDa increased with age and MnSOD(mitochondrial manganese superoxide dismutase) deficiency(PMID:12459471). Defects in ACO2 are the cause of infantile cerebellar-retinal degeneration(ICRD).

IMMUNOGEN INFORMATION

Immunogen

aconitase 2, mitochondrial

Synonyms

Gene symbol ACO2 Synonyms ACO2, Aconitase, aconitase 2, aconitase 2, mitochondrial, ACONM, Citrate hydro lyase

Observed MW

85 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

Q99798

IMAGES

Immunohistochemistry of paraffin-embedded human lung cancer using FNab00088(ACO2 antibody) at dilution of 1:50

Immunofluorescent analysis of ( 4% PFA ) fixed HeLa cells using FNab00088(ACO2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)

human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab00088(ACO2 antibody) at dilution of 1:400