anti- ACTL6A antibody

Uncover the diverse roles of ACTL6A in cellular functions with our Anti-ACTL6A Antibody. This indispensable research tool, available in a generous 100µg size, provides you with the precision and reliability needed to explore ACTL6A and its involvement in cellular processes.

ACTL6A, also known as actin-like protein 6A, is a member of the actin family of proteins and is implicated in various cellular functions, including chromatin remodeling and gene regulation. Our antibody is precision-engineered to specifically target ACTL6A with remarkable sensitivity. Rigorously validated, it ensures consistent and dependable results, empowering you to delve into the intricacies of cellular functions.

Utilizing state-of-the-art techniques, this antibody is sourced from rabbit hosts, featuring a polyclonal clonality that broadens its range of binding capabilities. Its versatility makes it an ideal choice for diverse applications, including Western blotting, immunoprecipitation, and immunofluorescence assays.

Whether you're unraveling the roles of ACTL6A in chromatin remodeling, studying gene regulation, or exploring ACTL6A-related conditions, our Anti-ACTL6A Antibody is your trusted research companion. Its high-quality formulation and generous 100µg size ensure it is an indispensable asset for your laboratory, enabling groundbreaking discoveries and contributions to cell biology research.

Empower your research with the precision and reliability of our Anti-ACTL6A Antibody. Secure your 100µg supply today and embark on a journey of discovery with confidence.

Product Name

ACTL6A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Involved in transcriptional activation and repression of select genes by chromatin remodeling(alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Component of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

IMMUNOGEN INFORMATION

Immunogen

actin-like 6A

Synonyms

Actin like 6A, Actin like protein 6A, Actin related protein Baf53a, ACTL6, ACTL6A, Arp4, ARPN BETA, ArpNbeta, BAF53, BAF53A, BRG1 associated factor 53A, INO80 complex subunit K, INO80K

Observed MW

47 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

O96019

IMAGES

Immunohistochemistry of paraffin-embedded human ovary using FNab00118(ACTL6A antibody) at dilution of 1:50

IP Result of anti-ACTL6A (IP:FNab00118, 4ug; Detection:FNab00118 1:500) with HeLa cells lysate 1200ug.

K-562 cells were subjected to SDS PAGE followed by western blot with FNab00118(ACTL6A antibody) at dilution of 1:1000