anti- ACTN4 antibody

Investigate the role of ACTN4 in cellular functions with our Anti-ACTN4 Antibody. This indispensable research tool, available in a generous 100µg size, provides you with the precision and reliability needed to explore ACTN4 and its potential involvement in various cellular processes.

ACTN4, also known as alpha-actinin-4, is a cytoskeletal protein involved in actin filament cross-linking and cellular functions. Our antibody is precision-engineered to specifically target ACTN4 with remarkable sensitivity. Rigorously validated, it ensures consistent and dependable results, instilling confidence in your exploration of cellular functions.

Produced using state-of-the-art techniques, this antibody is sourced from rabbit hosts, featuring a polyclonal clonality that broadens its range of binding capabilities. Its versatility makes it an ideal choice for diverse applications, including Western blotting, immunoprecipitation, and immunofluorescence assays.

Whether you're unraveling the role of ACTN4 in cytoskeletal dynamics, studying cellular organization, or investigating ACTN4-related conditions, our Anti-ACTN4 Antibody is your trusted research companion. Its high-quality formulation and generous 100µg size ensure it is an indispensable asset for your laboratory, enabling groundbreaking discoveries and contributions to cell biology research.

Empower your research with the precision and reliability of our Anti-ACTN4 Antibody. Secure your 100µg supply today and embark on a journey of discovery with confidence.

Product Name

ACTN4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein(Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation(PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions(By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA(PubMed:22351778).

IMMUNOGEN INFORMATION

Immunogen

actinin, alpha 4

Synonyms

ACTININ 4, actinin, alpha 4, ACTN4, Alpha actinin 4, DKFZp686K23158, F actin cross linking protein, FSGS, FSGS1, Non muscle alpha actinin 4

Observed MW

105 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, IP, FC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:500-1:5000; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

O43707

IMAGES

Immunohistochemistry of paraffin-embedded human breast cancer using FNab00123(ACTN4 antibody) at dilution of 1:100

IP Result of anti-ACTN4 (IP:FNab00123, 5ug; Detection:FNab00123 1:1000) with HeLa cells lysate 3000ug.

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00123(ACTN4 antibody) at dilution of 1:500