anti- ADAM17 antibody

Introducing our Anti-ADAM17 Antibody in a convenient 100µg size, a powerful tool for your research endeavors. ADAM17, also known as Tumor Necrosis Factor-α Converting Enzyme (TACE), is a pivotal player in various physiological processes, from cell signaling to inflammation. Understanding its functions demands precision, and our antibody delivers just that.

This Anti-ADAM17 Antibody is designed to provide exceptional sensitivity and specificity, allowing you to detect even trace amounts of ADAM17 with confidence. It's the key to unraveling the intricate roles of ADAM17 in your experiments.

Whether you're planning Western blotting experiments, immunoprecipitation assays, or immunofluorescence studies, this antibody adapts seamlessly to your research needs. Its versatility ensures you can explore ADAM17's functions across various experimental techniques.

What sets our Anti-ADAM17 Antibody apart is its reputation for reliable and reproducible results. You can trust it to deliver consistent outcomes, helping you advance your research with confidence.

Join researchers worldwide who rely on our antibodies to push the boundaries of scientific knowledge. Order your Anti-ADAM17 Antibody today and gain a powerful ally in your quest for discovery. Unlock the secrets of ADAM17 and embark on a journey towards groundbreaking insights in your field.

Product Name

ADAM17 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.

IMMUNOGEN INFORMATION

Immunogen

ADAM metallopeptidase domain 17

Synonyms

ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme

Observed MW

115 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

UNIPROT INFORMATION

UniProt ID

P78536

IMAGES

Immunohistochemistry of paraffin-embedded rat heart tissue slide using FNab00138( ADAM17 Antibody) at dilution of 1:100 

U-937 cells were subjected to SDS PAGE followed by western blot with FNab00138( ADAM17 Antibody) at dilution of 1:1000