anti- ADAM17-Specific antibody

Uncover the specific functions of ADAM17 with precision using our Anti-ADAM17-Specific Antibody, available in a 100µg size. ADAM17, also known as Tumor Necrosis Factor-α Converting Enzyme (TACE), plays a pivotal role in various physiological processes, including cell signaling and inflammation. Understanding its specific functions demands an antibody that targets ADAM17 exclusively, and our product delivers just that.

Our Anti-ADAM17-Specific Antibody offers unparalleled sensitivity and specificity, ensuring accurate detection and exploration of ADAM17's roles without unwanted cross-reactivity. Whether you're conducting Western blotting, immunoprecipitation, or immunofluorescence studies, this versatile antibody adapts seamlessly to your research needs. Its reputation for reliability ensures consistent and reproducible results, empowering you to advance your scientific inquiries.

Join researchers worldwide who trust our antibodies to drive their discoveries. Order your Anti-ADAM17-Specific Antibody today and embark on a journey to uncover the specific intricacies of ADAM17's functions, revolutionizing your research outcomes.

Product Name

ADAM17-Specific antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.

IMMUNOGEN INFORMATION

Immunogen

ADAM metallopeptidase domain 17

Synonyms

ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme

Observed MW

29 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P78536

IMAGES

Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab00139(ADAM17-Specific Antibody) at dilution of 1:200

human placenta tissue were subjected to SDS PAGE followed by western blot with FNab00139(ADAM17-Specific antibody) at dilution of 1:500