anti- Adenylosuccinate lyase antibody

Explore the world of molecular biology and metabolic pathways with confidence using our Anti-Adenylosuccinate Lyase Antibody, available in a 100µg size. Adenylosuccinate lyase (ADSL) is a vital enzyme involved in purine biosynthesis, playing a key role in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Understanding its functions is crucial for unraveling the complexities of nucleotide metabolism and its implications for various physiological processes.

Our Anti-Adenylosuccinate Lyase Antibody offers exceptional sensitivity and specificity, enabling you to delve deep into ADSL's roles with precision. Whether you're conducting Western blotting experiments, immunoprecipitation assays, or immunofluorescence studies, this versatile antibody seamlessly adapts to your research needs. Its reputation for reliability ensures consistent and reproducible results, empowering you to advance your scientific inquiries with confidence.

Purine metabolism is a fundamental process with wide-ranging implications in genetics, neurobiology, and human health. Researchers exploring disorders such as adenylosuccinate lyase deficiency or those investigating the broader landscape of nucleotide metabolism can trust our antibody as an invaluable tool.

Join researchers worldwide who rely on our antibodies to drive their discoveries. Order your Anti-Adenylosuccinate Lyase Antibody today and embark on a journey to unlock the secrets of ADSL, revolutionizing your research outcomes and contributing to advancements in the understanding of genetic diseases, neurological disorders, and the intricate world of nucleotide metabolism. Explore the intricacies of molecular biology with precision and confidence, armed with this powerful tool in your laboratory toolkit.

Product Name

Adenylosuccinate lyase antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

ADSL(adenylosuccinate lyase) is also named as AMPS, ASase, ASL and belongs to the lyase 1 family. It is an enzyme involved in 2 pathways of purine nucleotide metabolism and catalyzes cleavage of succinyl groups to yield fumarate(PMID:18524658). Defects in ADSL are the cause of adenylosuccinase deficiency(ADSL deficiency). In humans, mutations in ADSL lead to an inborn error of metabolism originally characterized by developmental delay, often with autistic features(PMID:20884265)..The ADSL enzymatic activity is reduced in lymphocytes and red blood cells of the patient with severe psychomotor retardation(PMID:9545543). It has 2 isoforms produced by alternative splicing.

IMMUNOGEN INFORMATION

Immunogen

adenylosuccinate lyase

Synonyms

Adenylosuccinase, adenylosuccinate lyase, ADSL, AMPS, ASASE, ASL

Observed MW

55 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, FC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P30566

IMAGES

Immunohistochemistry of paraffin-embedded human liver cancer using FNab00161(ADSL antibody) at dilution of 1:50

HeLa cells were subjected to SDS PAGE followed by western blot with FNab00161(ADSL antibody) at dilution of 1:400