anti- AFF1-Specific antibody

Introducing our state-of-the-art Anti-AFF1-Specific Antibody, now available in a convenient 100µg size, poised to elevate your research in the dynamic field of transcriptional regulation and gene expression.

The Anti-AFF1-Specific Antibody is meticulously crafted to meet the exacting standards of the scientific community. AFF1 (AF4/FMR2 Family Member 1) is a key player in transcriptional elongation and the formation of the super elongation complex (SEC), making it a central focus in studies of gene regulation. Our antibody offers exceptional specificity and sensitivity, making it an ideal choice for various applications, from chromatin immunoprecipitation to RNA polymerase II activity assays and more.

What distinguishes our Anti-AFF1-Specific Antibody is its exceptional performance. Rigorously tested and validated, it ensures reliable and reproducible results, effectively reducing experimental variability and saving you valuable time and resources.

With a 100µg size, this product strikes the perfect balance between cost-effectiveness and practicality, providing an ample supply of antibody for multiple experiments while minimizing wastage, aligning with our commitment to sustainable research practices.

Engineered with user-friendliness in mind, our Anti-AFF1-Specific Antibody is suitable for researchers at all levels, from novices to seasoned experts. It seamlessly integrates into various laboratory techniques, enhancing the precision and reliability of your experiments.

Empower your research with confidence, knowing you have the support of a high-quality, meticulously crafted Anti-AFF1-Specific Antibody at your fingertips. Step into the forefront of scientific discovery in transcriptional regulation and gene expression with a dependable partner by your side. Trust in our unwavering dedication to quality and innovation as you unravel the complexities of AFF1's roles in controlling gene expression and cellular function.

Product Name

AFF1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.

IMMUNOGEN INFORMATION

Immunogen

AF4/FMR2 family, member 1

Synonyms

AFF1, MLLT2, AF4 MLL, PBM1, AF 4

Observed MW

131 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

P51825

IMAGES

Immunofluorescence analysis of U2OS cells using FNab00195(AFF1-Specific antibody).

K-562 cells were subjected to SDS PAGE followed by western blot with FNab00195(AFF1-Specific antibody) at dilution of 1:1000