anti- AGER antibody

Introducing our state-of-the-art Anti-AGER Antibody, available in a convenient 100µg size, poised to revolutionize your research in the fields of immunology and receptor biology.

The Anti-AGER Antibody is meticulously crafted to meet the rigorous demands of the scientific community. AGER (Advanced Glycosylation End Product-Specific Receptor), also known as RAGE (Receptor for Advanced Glycation End Products), is a pivotal receptor involved in inflammation and immune responses, making it a central focus in the study of various diseases. Our antibody offers exceptional specificity and sensitivity, making it an ideal choice for a wide range of applications, from Western blotting to immunohistochemistry and more.

What truly sets our Anti-AGER Antibody apart is its outstanding performance. It has undergone rigorous testing and validation to ensure consistent and reproducible results, effectively reducing experimental variability and saving you valuable time and resources.

With a 100µg size, this product strikes the perfect balance between cost-effectiveness and usability. You'll have an ample supply of antibody for multiple experiments while minimizing wastage, aligning with our commitment to sustainable research practices.

Engineered with user-friendliness in mind, our Anti-AGER Antibody is suitable for researchers at all levels, from newcomers to seasoned experts. It seamlessly integrates into various laboratory techniques, enhancing the precision and reliability of your experiments.

Empower your research with confidence, knowing you have the support of a high-quality, meticulously crafted Anti-AGER Antibody at your disposal. Step into the forefront of scientific discovery in immunology and receptor biology with a dependable partner by your side. Trust in our unwavering dedication to quality and innovation as you explore the complexities of AGER's roles in immune responses and disease pathology.

Product Name

AGER antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

IMMUNOGEN INFORMATION

Immunogen

advanced glycosylation end product-specific receptor

Synonyms

AGER, RAGE

Observed MW

43 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q15109

IMAGES

Immunohistochemistry of paraffin-embedded human renal cell carcinoma tissue slide using FNab00209(AGER Antibody) at dilution of 1:200

mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab00209(AGER Antibody) at dilution of 1:600