anti- AIRE antibody

Delve into the world of immunology and autoimmune disorders with our cutting-edge Anti-AIRE Antibody, now available in a convenient 100µg size.

The Anti-AIRE Antibody, also known as Autoimmune Regulator, is meticulously designed to meet the exacting standards of the scientific community. AIRE plays a pivotal role in central tolerance and immune regulation, making it a central focus in studies of autoimmunity and immunotherapy. Our antibody offers exceptional specificity and sensitivity, making it an ideal choice for various applications, from immunohistochemistry to T-cell tolerance studies and more.

What truly distinguishes our Anti-AIRE Antibody is its outstanding performance. Rigorously tested and validated, it ensures consistent and reproducible results, effectively reducing experimental variability and saving you valuable time and resources.

With a 100µg size, this product strikes the perfect balance between cost-effectiveness and practicality, providing an ample supply of antibody for multiple experiments while minimizing wastage, aligning with our commitment to sustainable research practices.

Engineered with user-friendliness in mind, our Anti-AIRE Antibody is suitable for researchers at all levels, from novices to seasoned experts. It seamlessly integrates into various laboratory techniques, enhancing the precision and reliability of your experiments.

Empower your research with confidence, knowing you have the support of a high-quality, meticulously crafted Anti-AIRE Antibody at your disposal. Step into the forefront of scientific discovery in immunology and autoimmune disease mechanisms with a dependable partner by your side. Trust in our unwavering dedication to quality and innovation as you explore the intricacies of AIRE's roles in immune tolerance and autoimmune disorders.

Product Name

AIRE antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes(By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.

IMMUNOGEN INFORMATION

Immunogen

autoimmune regulator

Synonyms

AIRE, AIRE1, APECED, APECED protein, APS1, APSI, autoimmune regulator, PGA1

Observed MW

60 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:5000; IHC: 1:20-200

UNIPROT INFORMATION

UniProt ID

O43918

IMAGES