anti- AKAP8L antibody

Advance your research in intracellular signaling and protein-protein interactions with our state-of-the-art Anti-AKAP8L Antibody, now available in a convenient 100µg size.

The Anti-AKAP8L Antibody, also known as A-Kinase Anchor Protein 8-Like, is meticulously crafted to meet the demanding standards of the scientific community. AKAP8L is a critical scaffolding protein involved in organizing cellular signaling complexes, making it a central focus in studies of cell biology and signal transduction. Our antibody offers exceptional specificity and sensitivity, rendering it an ideal choice for various applications, from co-immunoprecipitation to live-cell imaging studies and more.

What truly sets our Anti-AKAP8L Antibody apart is its outstanding performance. Rigorously tested and validated, it ensures consistent and reproducible results, effectively reducing experimental variability and saving you valuable time and resources.

With a 100µg size, this product strikes the perfect balance between cost-effectiveness and practicality, providing an ample supply of antibody for multiple experiments while minimizing wastage, aligning with our commitment to sustainable research practices.

Engineered with user-friendliness in mind, our Anti-AKAP8L Antibody is suitable for researchers at all levels, from newcomers to seasoned experts. It seamlessly integrates into various laboratory techniques, enhancing the precision and reliability of your experiments.

Empower your research with confidence, knowing you have the support of a high-quality, meticulously crafted Anti-AKAP8L Antibody at your fingertips. Step into the forefront of scientific discovery in intracellular signaling and protein-protein interactions with a dependable partner by your side. Trust in our unwavering dedication to quality and innovation as you explore the intricacies of AKAP8L's roles in cellular signaling and signalosome assembly.

Product Name

AKAP8L antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Could play a role in constitutive transport element(CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export(PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA(PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis(PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta(PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8(PubMed:16980585). May be involved in regulation of pre-mRNA splicing(PubMed:17594903). (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters(PubMed:11884601). Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses(PubMed:11402034). In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity(PubMed:25034436).

IMMUNOGEN INFORMATION

Immunogen

A kinase(PRKA) anchor protein 8-like

Synonyms

A kinase anchor protein 8 like, AKAP8 like protein, AKAP8L, DKFZp434L0650, HA95, HAP95, Helicase A binding protein 95, Homologous to AKAP95 protein, NAKAP, NAKAP95, Neighbor of AKAP95

Observed MW

72 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:200-1:2000; IF: 1:20-200

UNIPROT INFORMATION

UniProt ID

Q9ULX6

IMAGES