anti- ALCAM antibody

Explore the intricate world of activated leukocyte cell adhesion molecule (ALCAM) with our highly specialized Anti-ALCAM Antibody, now available in a convenient 100µg size.

ALCAM is a cell adhesion molecule that plays a pivotal role in various physiological and pathological processes, including immune response regulation and cancer metastasis. Our antibody is meticulously designed to provide exceptional specificity and sensitivity, making it an ideal choice for a wide range of applications, from immunohistochemistry to flow cytometry and more.

What sets our Anti-ALCAM Antibody apart is its exceptional performance. Rigorously tested and validated, it ensures consistent and reproducible results, effectively reducing experimental variability and saving you valuable time and resources.

With a generous 100µg size, this product strikes the perfect balance between cost-effectiveness and practicality, offering ample antibody for multiple experiments while minimizing wastage. This aligns with our commitment to sustainable research practices.

Engineered for user-friendliness, our Anti-ALCAM Antibody is suitable for researchers at all levels, from novices to seasoned experts. It seamlessly integrates into various laboratory techniques, enhancing the precision and reliability of your experiments.

Empower your research with confidence, knowing you have the support of a high-quality, meticulously crafted Anti-ALCAM Antibody at your disposal. Step into the forefront of scientific discovery in cell adhesion and immune regulation with this essential tool and contribute to groundbreaking insights in the field.

Product Name

ALCAM antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts(PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6(PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6(PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM(PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow(PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction(PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions(PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation(By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons(By similarity). Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.

IMMUNOGEN INFORMATION

Immunogen

activated leukocyte cell adhesion molecule

Synonyms

ALCAM, CD166, CD166 antigen, FLJ38514, MEMD

Observed MW

110 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q13740

IMAGES