anti- ALK,CD246 antibody

Explore the intricacies of cell signaling with our specialized Anti-ALK, CD246 Polyclonal Antibody, now available in a convenient 100µg size. ALK, also known as CD246 (Cluster of Differentiation 246), is a receptor tyrosine kinase that plays a pivotal role in cell growth and development. Our meticulously crafted polyclonal antibody offers exceptional specificity and sensitivity, making it the perfect choice for a wide range of applications, from immunohistochemistry to Western blotting.

What sets our Anti-ALK, CD246 Polyclonal Antibody apart is its outstanding performance. It has undergone rigorous testing and validation to ensure consistent and reproducible results, effectively reducing experimental variability and saving valuable time and resources.

With a generous 100µg size, this product provides an ideal balance between cost-effectiveness and practicality, offering ample antibody for multiple experiments while minimizing wastage, aligning with our commitment to sustainable research practices.

Engineered for user-friendliness, our Anti-ALK, CD246 Polyclonal Antibody is suitable for researchers at all levels, whether you're a newcomer or an experienced scientist. It seamlessly integrates into various laboratory techniques, enhancing the precision and reliability of your experiments.

Unlock the full potential of your research with confidence, knowing you have the support of a high-quality, meticulously crafted Anti-ALK, CD246 Polyclonal Antibody. Explore the intricate world of cell signaling and contribute to groundbreaking insights in the field.

Product Name

ALK,CD246 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.

IMMUNOGEN INFORMATION

Immunogen

anaplastic lymphoma receptor tyrosine kinase

Synonyms

ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK

Observed MW

140-220 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9UM73

IMAGES