anti- ALKBH1 antibody

Explore the realm of ALKBH1 with our specialized Anti-ALKBH1 Antibody, available in a convenient 100µg size. ALKBH1 is a pivotal enzyme in RNA modification, influencing processes like mRNA stability and translation. Our meticulously crafted antibody delivers exceptional specificity and sensitivity, making it the perfect choice for various applications, from RNA immunoprecipitation to Western blotting.

What truly distinguishes our Anti-ALKBH1 Antibody is its exceptional performance. It has undergone rigorous testing and validation to ensure consistent and reproducible results, effectively reducing experimental variability and saving valuable time and resources.

With a generous 100µg size, this product offers a perfect balance between cost-effectiveness and practicality, providing ample antibody for multiple experiments while minimizing wastage, aligning with our commitment to sustainable research practices.

Engineered for user-friendliness, our Anti-ALKBH1 Antibody is suitable for researchers at all levels, whether you're a novice or an experienced scientist. It seamlessly integrates into various laboratory techniques, enhancing the precision and reliability of your experiments.

Unlock the full potential of your research with confidence, knowing you have the support of a high-quality, meticulously crafted Anti-ALKBH1 Antibody. Dive into the intricate world of RNA biology with this essential tool and contribute to groundbreaking insights in the field.

Product Name

ALKBH1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Dioxygenase that acts as a DNA demethylase(PubMed:18603530). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:18603530). Specifically demethylates DNA methylated on the 6th position of adenine(N(6)-methyladenosine) DNA. N(6)-methyladenosine(m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing(By similarity). Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation, but with low activity(PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites(PubMed:19959401). DNA lyase activity does not require alpha-ketoglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product(PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation(By similarity).

IMMUNOGEN INFORMATION

Immunogen

alkB, alkylation repair homolog 1(E. coli)

Synonyms

ABH, ABH1, alkB, ALKBH, ALKBH1, DNA lyase ABH1, hABH

Observed MW

44 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q13686

IMAGES