anti- Alpha-1-Antitrypsin antibody

Delve into the intricacies of protease inhibition with our highly specialized Anti-Alpha-1-Antitrypsin Antibody, now available in a convenient 100µg size. Alpha-1-antitrypsin is a pivotal serine protease inhibitor, primarily found in the bloodstream, where it plays a crucial role in protecting lung tissue from degradation by neutrophil elastase. This meticulously crafted antibody offers exceptional specificity and sensitivity, making it an ideal choice for a wide range of research applications, from enzyme assays to immunohistochemistry.

What truly sets our Anti-Alpha-1-Antitrypsin Antibody apart is its outstanding performance. It has undergone rigorous validation and testing to ensure consistent and reproducible results, effectively reducing experimental variability and optimizing resource utilization.

With a generous 100µg size, this product provides an ideal balance between cost-effectiveness and practicality, offering ample antibody for multiple experiments while minimizing wastage, aligning with our commitment to sustainable research practices.

Engineered for user-friendliness, our Anti-Alpha-1-Antitrypsin Antibody is suitable for researchers of all experience levels, from newcomers to seasoned scientists. It seamlessly integrates into various laboratory techniques, enhancing the precision and reliability of your experiments.

Contribute to a deeper understanding of protease regulation and lung health with confidence, knowing you have the support of a high-quality, meticulously crafted Anti-Alpha-1-Antitrypsin Antibody. Drive advances in pulmonary research and be part of groundbreaking discoveries in lung disease mechanisms.

Product Name

Alpha-1-Antitrypsin antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

SERPINA1 is the gene for a protein called alpha-1-antitrypsin(AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.

IMMUNOGEN INFORMATION

Immunogen

serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 1

Synonyms

A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, α1-antitrypsin

Observed MW

50 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:5000; IP: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:500-1:1000

UNIPROT INFORMATION

UniProt ID

P01009

IMAGES