anti- AMFR antibody

Embark on a journey into the world of cellular regulation and protein trafficking with our specialized Anti-AMFR Antibody, available in a 100µg size. The AMFR, or autocrine motility factor receptor, plays a crucial role in cell migration and intracellular signaling. This meticulously crafted antibody offers exceptional specificity and sensitivity, making it a valuable tool for various research applications, from immunoprecipitation to flow cytometry.

Our Anti-AMFR Antibody is characterized by its outstanding performance. It has undergone rigorous validation and testing to ensure consistent and reproducible results, effectively reducing experimental variability and optimizing resource utilization. With 100µg of antibody, this product provides ample material for multiple experiments, striking a balance between cost-effectiveness and practicality.

Engineered for user-friendliness, this antibody accommodates researchers of all experience levels, enhancing the precision and reliability of experiments across various laboratory techniques. Contribute to a deeper understanding of cellular motility and intracellular signaling with confidence, supported by our high-quality Anti-AMFR Antibody. Drive advancements in cell biology research and participate in groundbreaking discoveries in cell migration and metastasis.

Product Name

AMFR antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation(ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.

IMMUNOGEN INFORMATION

Immunogen

autocrine motility factor receptor

Synonyms

AMF receptor, isoform 2, AMFR, GP78, RING finger protein 45, RNF45

Observed MW

73 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, IP

Recommended Dilution

WB: 1:500-1:5000; IF: 1:10-1:100; IHC: 1:20-1:200; IP: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

Q9UKV5

IMAGES