anti- Aminoacylase 1 antibody

Explore the intricacies of amino acid metabolism and neuronal function with our highly specific Anti-Aminoacylase 1 Antibody, available in a convenient 100µg size. Aminoacylase 1 (ACY1) plays a pivotal role in the hydrolysis of N-acylated amino acids, influencing diverse biological processes, including neurotransmission and cellular detoxification.

Our meticulously crafted Anti-ACY1 Antibody offers exceptional specificity and sensitivity in various research applications, from immunohistochemistry to enzyme kinetics studies. It has undergone rigorous validation to ensure consistent and reproducible results, minimizing experimental variability and optimizing resource utilization.

With 100µg of high-quality antibody, this product provides ample material for multiple experiments, striking a balance between cost-effectiveness and practicality. Designed for ease of use, it accommodates researchers of all experience levels, enhancing the precision and reliability of experiments across various laboratory techniques.

Contribute to a deeper understanding of amino acid metabolism, neurotransmission, and cellular detoxification with confidence, supported by our high-quality Anti-ACY1 Antibody. Drive advancements in neurobiology and metabolic research and be part of groundbreaking discoveries in amino acid homeostasis.

Product Name

Aminoacylase 1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

IMMUNOGEN INFORMATION

Immunogen

aminoacylase 1

Synonyms

ACY 1, ACY1, ACY1D, ACYLASE, Aminoacylase 1

Observed MW

46 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

Q03154

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