anti- ATF4 antibody

Embark on a journey to explore stress response mechanisms with our Anti-ATF4 Polyclonal Antibody, available in a 100µg size. ATF4, a pivotal transcription factor, is a master regulator of genes involved in the integrated stress response (ISR), critical for cellular adaptation to various stressors.

Derived from rabbit hosts, this polyclonal antibody offers exceptional sensitivity and versatility for a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its polyclonal nature allows for recognition of multiple epitopes, enhancing its utility in diverse research contexts.

With 100µg at your disposal, you have a generous supply for multiple experiments, reducing the need for frequent reordering and ensuring the continuity of your research.

Don't miss the opportunity to illuminate the multifaceted functions of ATF4 in stress responses. With our Anti-ATF4 Polyclonal Antibody, you can confidently delve into your research and uncover the secrets hidden within this essential transcription factor.

Product Name

ATF4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcriptional activator. Binds the cAMP response element(CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088).

IMMUNOGEN INFORMATION

Immunogen

activating transcription factor 4(tax-responsive enhancer element B67)

Synonyms

ATF4, CREB 2, CREB2, DNA binding protein TAXREB67, TAXREB67, TXREB

Observed MW

50-58 kDa, 35-38 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP, FC

Recommended Dilution

WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P18848

IMAGES