anti- ATF4 antibody

Unveil the intricate integrated stress response (ISR) pathway with our Anti-ATF4 Monoclonal Antibody, available in a 100µg size. ATF4, a central transcription factor in the ISR, orchestrates cellular responses to various stressors, including oxidative stress and nutrient deprivation.

Our meticulously developed monoclonal antibody offers exceptional specificity and sensitivity, making it the ideal choice for a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The 100µg size provides an ample supply for your experiments, minimizing interruptions and allowing you to maintain the momentum of your research.

Illuminate the multifaceted roles of ATF4 in stress responses with confidence. With our Anti-ATF4 Monoclonal Antibody, you can navigate the intricacies of the ISR pathway and uncover its significance in cellular adaptation.

Product Name

ATF4 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcriptional activator. Binds the cAMP response element(CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088).

IMMUNOGEN INFORMATION

Immunogen

activating transcription factor 4

Synonyms

ATF4, CREB 2, CREB2, DNA binding protein TAXREB67, TAXREB67, TXREB

Observed MW

50-58 kDa

APPLICATION

Tested Application

ELISA, IHC, WB, IF

Recommended Dilution

WB: 1:1000-1:2000; IHC: 1:50-1:300; IF: 1:20-1:100

UNIPROT INFORMATION

UniProt ID

P18848

IMAGES