anti- ATX3,ATXN3 antibody

Illuminate your research on ATXN3 with our Anti-ATX3/ATXN3 Antibody. This 100µg antibody is your ticket to uncovering the intricate functions of ATXN3, a protein associated with neurodegenerative diseases.

Engineered for accuracy and reliability, this antibody excels in a range of applications, from Western blotting to immunohistochemistry. Its high specificity and sensitivity ensure that your experiments yield accurate and reproducible results, making it an indispensable tool in your laboratory.

ATXN3 is a critical player in the pathogenesis of diseases like Machado-Joseph disease, and this antibody empowers you to explore its functions. Whether you're investigating protein aggregation or studying diseases related to ATXN3, this antibody is your trusted research partner.

Invest in scientific excellence by ordering your Anti-ATX3/ATXN3 Antibody today and embark on a journey towards a deeper understanding of neurodegenerative disorders.

Product Name

ATX3,ATXN3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

ATXN3, which has deubiquitinase activity and act as a component of the ubiquitin proteasome system, plays a role in transcriptional regulation and neuroprotection. ATXN3 interacts with RAD23, HHR23A and HHR23B, involves in the pathology of MJD. ATXN3 is a mixed-linkage, chain-editing enzyme and that the UIM region of ATXN3 regulates its substrate specificity. Contains an N-terminal deubiquitinating domain, called the Josephin domain, followed by 2 ubiquitin-interacting motifs (UIMs) and a polyQ tract near the C terminus. ATXN3 can be phosphorylated in a protein casein kinase-2-dependent manner, thus the MW would be larger than the predicted one.

IMMUNOGEN INFORMATION

Immunogen

ataxin 3

Synonyms

AT3, ataxin 3, ATX3, ATXN3, JOS, MJD, MJD1, SCA3

Observed MW

38 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P54252

IMAGES