anti- BRE antibody

Delve into the intricacies of BRE (Brain and Reproductive Organ-Expressed Protein) with our Anti-BRE Antibody, available in a 100µg size. This high-quality antibody is your indispensable tool for unraveling the roles and functions of BRE in neural development, reproductive biology, and cellular homeostasis.

Engineered for precision and reliability, this antibody offers exceptional specificity and sensitivity, ensuring accurate results in applications such as western blotting, immunohistochemistry, and immunoprecipitation. Whether you're studying BRE's involvement in neuronal differentiation, gametogenesis, or stress responses, this antibody empowers your research with accuracy and versatility.

BRE is a multifunctional protein expressed in various tissues, including the brain and reproductive organs, and is associated with diverse cellular processes, including cell cycle regulation, apoptosis, and DNA repair.

With our Anti-BRE Antibody, you can explore BRE's functionality, investigate its interactions with regulatory proteins, and potentially advance research in neurobiology and reproductive sciences. Elevate your research in neural development and reproductive health with this precision antibody.

Product Name

BRE antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks(DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX(PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer(PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates(PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity(PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1(PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression(PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide(LPS) via its role in IFNAR1 deubiquitination(PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect(PubMed:15465831).

IMMUNOGEN INFORMATION

Immunogen

brain and reproductive organ-expressed(TNFRSF1A modulator)

Synonyms

BRCC45

Observed MW

44 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NXR7

IMAGES