anti- CD46 antibody

Venture into the world of immune regulation and complement control with our Anti-CD46 Antibody, available in a 100µg size. CD46, also known as Membrane Cofactor Protein (MCP), plays a crucial role in protecting cells from complement-mediated lysis, and this monoclonal antibody offers exceptional specificity for precise targeting in your experiments.

Whether you're involved in immunohistochemistry, flow cytometry, or functional complement assays, this antibody provides the consistency and accuracy you need. It is an indispensable tool for advancing your understanding of CD46-mediated immune responses and its implications in autoimmunity and infectious diseases.

Empower your research and contribute to scientific advancements with the trusted performance of our Anti-CD46 Antibody. With this tool at your disposal, you'll be better equipped to unravel the complexities of CD46-mediated immune regulation and complement control.

Product Name

CD46 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. Acts as a receptor for adenovirus subgroup B2 and Ad3, cultured measles virus and herpesvirus 6(PubMed:10972291, PubMed:12663806, PubMed:12724329, PubMed:12915534, PubMed:14566335, PubMed:15047806, PubMed:15078926, PubMed:15919905, PubMed:16254377). May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes(PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

IMMUNOGEN INFORMATION

Immunogen

CD46 molecule, complement regulatory protein

Synonyms

MCP, MIC10

Observed MW

50-56 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:500-1:1000; IP: 1:200-1:1000

UNIPROT INFORMATION

UniProt ID

P15529

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