anti- CHMP1A antibody

Step into the world of endosomal membrane remodeling with our Anti-CHMP1A Antibody, available in a 100µg size. Charged multivesicular body protein 1A (CHMP1A) is a key player in the ESCRT-III complex, essential for membrane scission and vesicle formation.

This meticulously designed polyclonal antibody offers unparalleled specificity and sensitivity, ensuring accurate detection of CHMP1A protein in your experiments. Researchers studying membrane abscission, viral release, or related areas will benefit from the precision and reliability of this antibody.

Our Anti-CHMP1A Antibody undergoes stringent quality control, guaranteeing consistent and reproducible results. Take your research on membrane dynamics and intracellular vesicle formation to the next level with this essential tool.

Product Name

CHMP1A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Probable peripherally associated component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group(PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

IMMUNOGEN INFORMATION

Immunogen

chromatin modifying protein 1A

Synonyms

CHMP1, CHMP1A, chromatin modifying protein 1A, hVps46 1, KIAA0047, PCOLN3, PRSM1, Vps46 1

Observed MW

33 kDa, 25 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9HD42

IMAGES