anti- COPS8 antibody

Journey into the fascinating world of protein degradation and intracellular signaling with our Anti-COPS8 Antibody, meticulously developed and conveniently available in a 100µg size. COPS8, also known as CSN8, is a subunit of the COP9 signalosome (CSN) complex, involved in the regulation of protein stability and cellular responses to external signals. This high-quality antibody serves as your essential tool for investigating the dynamic processes of protein ubiquitination and deubiquitination.

Our antibody is thoughtfully designed and rigorously validated to ensure specificity and sensitivity, ensuring accurate and reproducible results in your experiments. Whether you're exploring proteasomal degradation pathways, cellular responses to stress, or the role of COPS8 in cancer biology, this antibody is your trusted research partner.

The 100µg size offers a generous supply of antibody to support your experiments, reducing the inconvenience of frequent reordering and ensuring uninterrupted progress in your research endeavors. Choose our Anti-COPS8 Antibody to advance your scientific exploration of protein regulation and contribute to a deeper understanding of cellular responses to environmental cues.

Unraveling the intricacies of COPS8's role in protein stability and signaling is essential for deciphering the complexities of cellular responses to stimuli and their implications in various diseases. Our antibody empowers you to delve into this intriguing area of research, potentially paving the way for novel therapeutic strategies and improved patient outcomes.

Product Name

COPS8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

IMMUNOGEN INFORMATION

Immunogen

COP9 constitutive photomorphogenic homolog subunit 8(Arabidopsis)

Synonyms

COP9, COP9 homolog, COPS8, CSN8, hCOP9, SGN8, Signalosome subunit 8

Observed MW

23 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q99627

IMAGES