anti- CX3CL1 antibody

Our Anti-CX3CL1 Polyclonal Antibody, available in a 100µg size, is a versatile and essential tool for researchers exploring the complexities of chemokines. CX3CL1, also known as fractalkine, is a key chemokine involved in immune cell adhesion and migration, making it a focal point of research in various fields.

As a polyclonal antibody, it offers enhanced sensitivity and versatility, enabling you to delve deep into the molecular mechanisms of immune cell behavior and inflammation. We have meticulously validated the specificity of this antibody to ensure precise and reproducible results in your experiments.

Its compact size allows for a wide range of experimental applications, from immunohistochemistry to flow cytometry. Whether you're unraveling the secrets of immune cell adhesion or investigating therapeutic targets, our Anti-CX3CL1 Polyclonal Antibody is a trusted resource that will advance your scientific investigations. Trust in its quality to propel your research forward.

Product Name

CX3CL1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1(PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site(site 1) in integrins. In the absence of CX3CR1, binds to a second site(site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1(PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium(PubMed:9024663, PubMed:9177350).

IMMUNOGEN INFORMATION

Immunogen

chemokine(C-X3-C motif) ligand 1

Synonyms

FKN, NTT, SCYD1

Observed MW

90-100 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P78423

IMAGES