anti- CYLD antibody

Our Anti-CYLD Antibody, available in a 100µg size, is a critical tool for researchers exploring the protein CYLD, a deubiquitinase enzyme involved in regulating various cellular processes, including inflammation and cell cycle control.

Understanding the functions and interactions of CYLD is essential for unraveling its contributions to normal cellular homeostasis and its implications in diseases such as cancer and inflammatory disorders. Our antibody has been rigorously validated for specificity and sensitivity, ensuring precise and reproducible results in your experiments.

Its compact size allows for versatility in applications, whether you're conducting immunoprecipitation, immunofluorescence microscopy, or investigating ubiquitin signaling pathways. Trust in the quality of our Anti-CYLD Antibody to accelerate your scientific investigations and contribute to advancements in cell biology and disease research.

Product Name

CYLD antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation(PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation(PubMed:12917690). Negative regulator of Wnt signaling(PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules(PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis(PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis(PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation(PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis(By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation(By similarity).

IMMUNOGEN INFORMATION

Immunogen

cylindromatosis(turban tumor syndrome)

Synonyms

CYLD1, KIAA0849

Observed MW

110 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

Q9NQC7

IMAGES