anti- CYP46A1 antibody

Our Anti-CYP46A1 Antibody, available in a 100µg size, is a vital tool for researchers studying the cytochrome P450 enzyme CYP46A1, also known as cholesterol 24-hydroxylase, involved in the metabolism of cholesterol in the brain.

CYP46A1 plays a crucial role in the conversion of cholesterol into 24S-hydroxycholesterol, facilitating its elimination from the brain. Understanding the functions and regulation of CYP46A1 is essential for unraveling its contributions to cholesterol homeostasis in the central nervous system and its implications in neurodegenerative diseases.

Our antibody has undergone rigorous validation for specificity and sensitivity, ensuring precise and reproducible results in your experiments. Its compact size allows for versatility in applications, whether you're conducting cholesterol metabolism studies, investigating neurodegenerative pathways, or exploring therapeutic targets for brain disorders. Trust in the quality of our Anti-CYP46A1 Antibody to accelerate your scientific investigations and contribute to advancements in neuroscience and neurology research.

Product Name

CYP46A1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

IMMUNOGEN INFORMATION

Immunogen

cytochrome P450, family 46, subfamily A, polypeptide 1

Synonyms

CYP46

Observed MW

57 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

Q9Y6A2

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