anti- CYP4F3 antibody

Our Anti-CYP4F3 Antibody, available in a 100µg size, is a vital tool for researchers studying the cytochrome P450 enzyme CYP4F3, known for its role in the metabolism of arachidonic acid and other fatty acids.

CYP4F3 is involved in the oxidation of fatty acids and the synthesis of lipid mediators that play essential roles in inflammation and cell signaling. Understanding the functions and regulation of CYP4F3 is essential for unraveling its contributions to lipid metabolism and its implications in inflammatory responses and cell physiology.

Our antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in your experiments. Its compact size allows for versatility in applications, whether you're conducting lipid metabolism studies, investigating inflammatory pathways, or exploring therapeutic targets. Trust in the quality of our Anti-CYP4F3 Antibody to accelerate your scientific investigations and contribute to advancements in lipidomics and inflammation research.

Product Name

CYP4F3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid(20-HETE)(PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A(PubMed:11461919). Also converts eicosapentaenoate(EPA) to 20-hydroxyeicosapentaenoate(20-OH-EPA)(PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate(DHA) to 22-hydroxydocosahexaenoate(PubMed:16820285).

IMMUNOGEN INFORMATION

Immunogen

cytochrome P450, family 4, subfamily F, polypeptide 3

Synonyms

LTB4H

Observed MW

60 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q08477

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