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FineTest

SKU(재고 관리 코드):FNab02553

anti- DTX1 antibody

anti- DTX1 antibody

size

Step into the world of cellular signaling and signal transduction with our meticulously designed Anti-DTX1 Antibody, now available in a 100µg size. Deltex E3 Ubiquitin Ligase 1 (DTX1) is a central player in various cellular processes, making it an indispensable tool for researchers studying signal transduction, cell fate determination, and immune responses.

This highly specific antibody empowers you to delve into the intricacies of DTX1 and its functions with precision and confidence. It has undergone rigorous quality control to ensure accuracy and reproducibility in your experiments, making it an ideal choice for researchers studying Notch signaling pathways, cell differentiation, and disease mechanisms.

DTX1 is crucial for cellular responses and is often implicated in immune system function and disease-related pathways. Whether your research focuses on immune signaling cascades, developmental processes, or disease mechanisms, this antibody will be your trusted companion.

Product Name

DTX1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity(By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB(Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

IMMUNOGEN INFORMATION

Immunogen

deltex homolog 1(Drosophila)

Observed MW

67-72,58-63 kDa

APPLICATION

Tested Application

ELISA, IF, IHC

Recommended Dilution

IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q86Y01

IMAGES

 

Immunohistochemistry of paraffin-embedded human colon cancer using FNab02553(DTX1 antibody) at dilution of 1:100
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