anti- EDEM2 antibody

Unravel the intricate world of endoplasmic reticulum-associated degradation (ERAD) pathways with our Anti-EDEM2 Antibody, now available in a 100µg size. EDEM2, also known as ER Degradation-Enhancing Alpha-Mannosidase-Like Protein 2, plays a critical role in the disposal of misfolded proteins from the ER.

This antibody is meticulously validated for specificity, ensuring that your research on ERAD, protein quality control, and ER stress response is supported by a dependable tool.

EDEM2's significance in ER protein quality control and its role in maintaining cellular proteostasis have made it a subject of substantial research interest in the fields of cell biology and protein homeostasis. Whether your research focuses on ER stress, misfolded protein degradation, or protein quality control mechanisms, this antibody is an invaluable addition to your toolkit.

Order your 100µg vial today and embark on an exploration of EDEM2, its role in ERAD pathways, and its implications in various cellular processes.

Product Name

EDEM2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Initiates the endoplasmic reticulum-associated degradation(ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2(PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.

IMMUNOGEN INFORMATION

Immunogen

ER degradation enhancer, mannosidase alpha-like 2

Synonyms

C20orf31, C20orf49

Observed MW

60-65 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q9BV94

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