anti- EIF2AK3 antibody

Delve into the multifaceted world of EIF2AK3 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3) with our Anti-EIF2AK3 Antibody, available in a 100µg size. EIF2AK3, also known as PERK, is a critical regulator of the unfolded protein response (UPR), which is central to endoplasmic reticulum (ER) stress and protein quality control.

This antibody is meticulously validated for specificity, ensuring that your research on EIF2AK3's role in ER stress, its kinase activity, and its implications in cellular homeostasis is strengthened by a reliable tool.

EIF2AK3's significance in the UPR and its role in maintaining protein folding fidelity have made it a subject of substantial research interest. Whether your studies delve into ER stress, the UPR pathway, or protein quality control, this antibody is an indispensable addition to your scientific toolkit.

Order your 100µg vial today and delve into the multifaceted world of EIF2AK3 and its contributions to cellular homeostasis.

Product Name

EIF2AK3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2(eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response(UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response(UPR)-induced G1 growth arrest due to the loss of cyclin-D1(CCND1). Involved in control of mitochondrial morphology and function.

IMMUNOGEN INFORMATION

Immunogen

eukaryotic translation initiation factor 2-alpha kinase 3

Synonyms

PEK, PERK

Observed MW

140 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NZJ5

IMAGES