anti- EPHA7 antibody

Delve into the fascinating world of cell adhesion and axon guidance with our Anti-EPHA7 Antibody, an essential tool for studying EPHA7, a member of the Eph receptor family. With 100µg of high-quality antibody, you have the precision and reliability required for your experiments.

EPHA7 plays a pivotal role in regulating neuronal development and cell signaling, impacting various physiological processes. Our antibody is rigorously tested for specificity and sensitivity, making it ideal for techniques such as immunoblotting, immunoprecipitation, and immunofluorescence.

The Anti-EPHA7 Antibody is your essential tool for exploring EPHA7's functions with precision, contributing to a deeper understanding of cellular communication. Whether you're engaged in basic research or neuroscience studies, this antibody is a valuable asset, providing you with the confidence to advance your scientific inquiries and make significant strides in your work.

Product Name

EPHA7 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

IMMUNOGEN INFORMATION

Immunogen

EPH receptor A7

Synonyms

EHK3, HEK11

APPLICATION

Tested Application

ELISA

UNIPROT INFORMATION

UniProt ID

Q15375