anti- ERK1/2 antibody

Enhance your research capabilities with our set of two Anti-ERK1/2 Antibodies, designed to empower your investigations into the complex signaling pathways regulated by extracellular signal-regulated kinases 1 and 2 (ERK1/2). Each vial contains 100µg of high-quality antibody, providing you with the precision and reliability needed for your experiments.

ERK1 and ERK2 are key components of the mitogen-activated protein kinase (MAPK) pathway, governing various cellular processes, including cell proliferation, differentiation, and survival. Our antibodies are meticulously tested for specificity and sensitivity, making them ideal for techniques such as immunoblotting, immunoprecipitation, and immunofluorescence.

The Anti-ERK1/2 Antibody set is your essential resource for investigating the multifaceted roles of ERK1/2 in cell signaling and their contributions to a wide range of physiological and pathological conditions. Whether you're engaged in basic research or exploring diseases related to MAPK signaling, this antibody set is an invaluable asset, providing you with the confidence to advance your scientific inquiries and make significant strides in your work.

Product Name

ERK1/2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

IMMUNOGEN INFORMATION

Immunogen

mitogen-activated protein kinase 1

Synonyms

ERK, ERK 2, ERK1/2, ERK2, ERT1, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MAPK 2, MAPK1, MAPK2, p40, p41, p41mapk, p42 MAPK, P42MAPK, PRKM1, PRKM2

Observed MW

40 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

P28482

IMAGES