anti- EXOSC10 antibody

Elevate your research with our Anti-EXOSC10 Antibody, a crucial tool for molecular biologists and geneticists. EXOSC10, a core component of the exosome complex, plays a pivotal role in RNA degradation and processing, making it a central focus for a wide range of studies. This high-quality antibody, conveniently provided in a double pack of 100µg each, ensures you have the resources needed to push the boundaries of your research.

Our Anti-EXOSC10 Antibody has undergone meticulous development and rigorous validation, guaranteeing exceptional specificity and sensitivity. With a reliable antibody in your toolkit, you can explore the multifaceted functions of EXOSC10, including its involvement in RNA quality control, and mRNA degradation. This ensures that your research is built on a solid foundation of accurate and reproducible results.

With the convenience of two 100µg vials, you can focus on your research without constant reordering, ensuring cost-efficiency and peace of mind. Whether your experiments involve cell culture, tissue samples, or other biological systems, this antibody seamlessly adapts to a wide range of research applications.

Product Name

EXOSC10 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity(By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

IMMUNOGEN INFORMATION

Immunogen

exosome component 10

Synonyms

PMSCL, PMSCL2, RRP6

APPLICATION

Tested Application

ELISA, IHC, IF

Recommended Dilution

IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q01780

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