anti- EXOSC2 antibody

Experience the cutting-edge of molecular biology research with our Anti-EXOSC2 Antibody, a versatile and reliable tool for your scientific endeavors. As a pivotal subunit of the exosome complex, EXOSC2 is central to RNA processing and degradation, and our high-quality polyclonal antibody, available in a convenient 100µg size, is the ideal choice for researchers across various fields.

Our Anti-EXOSC2 Antibody is the result of meticulous development and rigorous validation, ensuring exceptional specificity and sensitivity. This antibody is designed to empower you to explore EXOSC2's multifaceted functions, from RNA degradation to mRNA surveillance, providing accurate and consistent results for your research needs.

The 100µg size minimizes the need for frequent reordering, offering a cost-effective solution for your laboratory. Whether your research involves cell culture, tissue samples, or other experimental systems, this antibody seamlessly adapts to a wide range of research applications.

Product Name

EXOSC2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

IMMUNOGEN INFORMATION

Immunogen

exosome component 2

Synonyms

RRP4

Observed MW

30-33 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q13868

IMAGES