anti- EXOSC2 antibody

Welcome to the forefront of molecular biology research with our Anti-EXOSC2 Antibody, an indispensable tool designed to amplify your scientific explorations. EXOSC2, a vital subunit of the exosome complex, plays a pivotal role in RNA processing and degradation, making it a key focus for a wide range of studies. This premium polyclonal antibody, available in a convenient 100µg size, is your trusted partner for unraveling the secrets of RNA biology.

Our Anti-EXOSC2 Antibody has been meticulously developed and rigorously validated to provide exceptional specificity and sensitivity. It empowers you to explore the multifaceted functions of EXOSC2, including its role in RNA degradation, mRNA surveillance, and more. This antibody ensures reliable and accurate results, giving you the confidence to pursue your research goals.

With 100µg at your disposal, this antibody minimizes the need for frequent reordering, maximizing cost-efficiency. Whether your research spans cell culture, tissue samples, or other experimental systems, this antibody seamlessly adapts to diverse research applications.

Product Name

EXOSC2 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

IMMUNOGEN INFORMATION

Immunogen

exosome component 2

Synonyms

RRP4

Observed MW

33 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

Q13868

IMAGES