anti- EXOSC8 antibody

Dive into the fascinating world of RNA biology with our Anti-EXOSC8 Antibody. EXOSC8 is an integral component of the RNA exosome complex, a key player in RNA degradation and quality control. This 100µg polyclonal antibody is your essential companion in exploring the intricate workings of cellular RNA metabolism.

Our antibody is rigorously tested to ensure specificity and reliability in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its exceptional sensitivity and low background guarantee precise and reproducible results for your research.

As you investigate the roles of EXOSC8, you'll uncover its involvement in maintaining RNA stability and processing. This knowledge has far-reaching implications, particularly in understanding diseases associated with RNA dysregulation. Trust in the quality and specificity of our Anti-EXOSC8 Antibody to advance your research pursuits.

Product Name

EXOSC8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.

IMMUNOGEN INFORMATION

Immunogen

exosome component 8

Synonyms

OIP2, RRP43

Observed MW

30-35 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q96B26

IMAGES