anti- EXOSC9 antibody

Uncover the secrets of cellular RNA metabolism and degradation with our Anti-EXOSC9 Antibody. EXOSC9 is a key player in the RNA exosome complex, responsible for RNA quality control and processing. This 100µg polyclonal antibody is your ticket to unlocking the intricacies of this crucial cellular machinery.

Our antibody undergoes rigorous testing to ensure specificity and reliability in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It boasts exceptional sensitivity and low background, providing you with accurate and reproducible results for your research.

By studying EXOSC9, you can gain insights into the regulation of RNA stability and processing, with potential implications in various disease states. Trust our Anti-EXOSC9 Antibody to provide the precision and reliability you need for your investigations.

Product Name

EXOSC9 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.

IMMUNOGEN INFORMATION

Immunogen

exosome component 9

Synonyms

PMSCL1

Observed MW

65 kDa

APPLICATION

Tested Application

ELISA, IHC, IF, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q06265

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