anti- EYA1 antibody

Step into the world of developmental biology and signaling with our Anti-EYA1 Antibody, an essential tool for investigating EYA1's role in organogenesis and tissue-specific processes. EYA1 is known for its involvement in cellular development and signaling pathways, making it a central target for researchers exploring developmental biology and disease mechanisms. This high-quality antibody, available in a 100µg size, is your trusted partner in unraveling the intricacies of EYA1's functions.

Our meticulously developed and rigorously validated Anti-EYA1 Antibody ensures exceptional specificity and sensitivity, providing you with reliable and accurate results in your research. Whether you're studying organ development, signaling pathways, or other aspects of cellular function, this antibody offers versatility and high performance.

The 100µg size minimizes the need for frequent reordering, allowing you to focus more on your research and less on supply management. Whether you're working with tissue samples, cell cultures, or other experimental systems, this antibody seamlessly adapts to a wide range of research applications.

Product Name

EYA1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5(By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX(H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress(PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis(By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues(in vitro)(By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears(By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2(By similarity).

IMMUNOGEN INFORMATION

Immunogen

eyes absent homolog 1(Drosophila)

Observed MW

60 kDa ;50 kDa

APPLICATION

Tested Application

ELISA, IHC, WB, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q99502

IMAGES