anti- FBXO18 antibody

Unlock the potential of your research with our Anti-FBXO18 Antibody, an essential tool for investigators in the field of ubiquitination, protein degradation, and cellular regulation. FBXO18, a member of the F-box protein family, plays a vital role in substrate recognition for the Skp1-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Our high-quality antibody, available in a 100µg size, empowers you to delve into the functions and regulatory mechanisms of FBXO18 with precision and sensitivity.

Key Features:

• Precision and Sensitivity: Our Anti-FBXO18 Antibody is meticulously developed and rigorously validated to ensure specificity and reliability in your experiments.
• Ubiquitination Research: Investigate the crucial role of FBXO18 in the ubiquitination pathway and substrate degradation.
• Protein Degradation: Explore the mechanisms behind protein turnover and cellular regulation, essential in various cellular processes.
• 100µg Size: With 100µg of antibody per vial, you reduce the need for frequent reordering, ensuring a seamless research experience.
• Whether you're studying the role of FBXO18 in cellular signaling pathways, its implications in disease, or its interactions with specific substrates, this antibody is your gateway to in-depth research.

Elevate your research to new heights and make significant contributions to our understanding of cellular regulation and protein degradation. Order your Anti-FBXO18 Antibody today and advance your research with confidence.

Product Name

FBXO18 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks(PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination(PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress(PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal(PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location(PubMed:25585578).

IMMUNOGEN INFORMATION

Immunogen

F-box protein, helicase, 18

Synonyms

FBH1, FBX18

Observed MW

118-123 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q8NFZ0

IMAGES